Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SPARC Overexpression Promotes Liver Cancer Cell Proliferation and Tumor Growth

29 Nov 2021

Abstract excerpt

Background: Secreted protein acidic and rich in cysteine (SPARC) plays an important role in cancer development. The roles of SPARC in the liver hepatocellular carcinoma (LIHC) are unclear. Methods: GEPIA2 and UALCAN were used to analyze the SPARC mRNA expression levels in LIHC based on the TCGA database. The GEO database was used to verify the analysis results. Immunohistochemical (IHC) analysis was used to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Dental Protein Studies
Share to Bone health and treatments
Share to Curcumin's Biomedical Applications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34912848
DOI: 10.3389/fmolb.2021.775743

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SPARC Overexpression Promotes Liver Cancer Cell Proliferation and Tumor GrowthPMID 34912848Read ↗

Associations of tumor suppressor SPARCL1 with cancer progression and prognosisSemantic proximity Read ↗

SPARCL1 Is a Novel Prognostic Biomarker and Correlates with Tumor Microenvironment in Colorectal CancerSemantic proximity Read ↗

Activation of the PI3K-AKT signaling pathway by SPARC contributes to the malignant phenotype of cholangiocarcinoma cells.Semantic proximity Read ↗

SPARCL1 suppresses the proliferation and migration of human ovarian cancer cells via the MEK/ERK signalingSemantic proximity Read ↗

Downregulation of SPARC expression decreases gastric cancer cellular invasion and survivalSemantic proximity Read ↗

Inhibition of endogenous SPARC enhances pancreatic cancer cell growth: modulation by FGFR1-III isoform expression.Semantic proximity Read ↗

Secreted Protein Acidic and Rich in Cysteine (SPARC) Enhances Cell Proliferation, Migration, and Epithelial Mesenchymal Transition, and SPARC Expression is Associated with Tumor Grade in Head and Neck Cancer.Semantic proximity Read ↗

An overview of esophageal squamous cell carcinoma proteomicsSemantic proximity Read ↗

SPARC promotes pancreatic cancer cell proliferation and migration through autocrine secretion into the extracellular milieuSemantic proximity Read ↗

Identifying liver metastasis-related hub genes in breast cancer and characterizing SPARCL1 as a potential prognostic biomarkerSemantic proximity Read ↗

Identification of SHC2 as a prognostic biomarker: from pan-cancer analysis to colon adenocarcinoma validationSemantic proximity Read ↗

hsa-miR-29c-3p regulates biological function of colorectal cancer by targeting SPARCSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.