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Aberrant methylation of the SPARC gene promoter and its clinical implication in gastric cancer

17 Dec 2014

Abstract excerpt

Secreted protein acidic and rich in cysteine (SPARC) gene has been shown to be epigenetically silenced in several cancers. We investigated the loss of expression and promoter methylation of this tumor suppressor gene in gastric cancers and correlated the data with clinicopathological features. We observed the loss of SPARC mRNA and SPARC protein expression in 7 of 10 (70%) gastric cancer cell lines. Upon...

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PMID: 25516351
DOI: 10.1038/srep07035

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