Article
Characterization of a natural mutator variant of human DNA polymerase lambda which promotes chromosomal instability by compromising NHEJ.
PloS one - 6 Oct 2009
Terrados Gloria, Capp Jean-Pascal, Canitrot Yvan, García-Díaz Miguel, Bebenek Katarzyna, Kirchhoff Tomas, Villanueva Alberto, Boudsocq François, Bergoglio Valérie, Cazaux Christophe, Kunkel Thomas A, Hoffmann Jean-Sébastien, Blanco Luis
Abstract excerpt
BACKGROUND: DNA polymerase lambda (Pollambda) is a DNA repair polymerase, which likely plays a role in base excision repair (BER) and in non-homologous end joining (NHEJ) of DNA double-strand breaks (DSB). PRINCIPAL FINDINGS: Here, we described a novel natural allelic variant of human Pollambda (hPollambda) characterized by a single nucleotide polymorphism (SNP), C/T variation in the first base of codon 438,...
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