Article
Human DNA polymerase beta mutations allowing efficient abasic site bypass.
The Journal of biological chemistry - 4 Feb 2011
Gieseking Sonja, Bergen Konrad, Di Pasquale Francesca, Diederichs Kay, Welte Wolfram, Marx Andreas
Abstract excerpt
The DNA of every cell in the human body gets damaged more than 50,000 times a day. The most frequent damages are abasic sites. This kind of damage blocks proceeding DNA synthesis by several DNA polymerases that are involved in DNA replication and repair. The mechanistic basis for the incapability of these DNA polymerases to bypass abasic sites is not clarified. To gain insights into the mechanistic basis, we...
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