Article
DNA Polymerase and dRP-lyase activities of polymorphic variants of human Pol ι.
The Biochemical journal - 16 Apr 2021
Shilkin Evgeniy S, Gromova Anastasia S, Smal Margarita P, Makarova Alena V
Abstract excerpt
Y-family DNA polymerase iota (Pol ι) is involved in DNA damage response and tolerance. Mutations and altered expression level of POLI gene are linked to a higher incidence of cancer. We biochemically characterized five active site polymorphic variants of human Pol ι: R71G (rs3218778), P118L (rs554252419), I236M (rs3218784), E251K (rs3218783) and P365R (rs200852409). We analyzed fidelity of nucleotide...