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The Role of Natural Polymorphic Variants of DNA Polymerase β in DNA Repair

21 Feb 2022

Abstract excerpt

DNA polymerase β (Polβ) is considered the main repair DNA polymerase involved in the base excision repair (BER) pathway, which plays an important part in the repair of damaged DNA bases usually resulting from alkylation or oxidation. In general, BER involves consecutive actions of DNA glycosylases, AP endonucleases, DNA polymerases, and DNA ligases. It is known that protein-protein interactions of Polβ with...

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PMID: 35216513
DOI: 10.3390/ijms23042390

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