Article
Human Polβ Natural Polymorphic Variants G118V and R149I Affects Substate Binding and Catalysis.
International journal of molecular sciences - 20 Mar 2023
Kladova Olga A, Tyugashev Timofey E, Mikushina Elena S, Soloviev Nikita O, Kuznetsov Nikita A, Novopashina Daria S, Kuznetsova Aleksandra A
Abstract excerpt
DNA polymerase β (Polβ) expression is essential for the cell's response to DNA damage that occurs during natural cellular processes. Polβ is considered the main reparative DNA polymerase, whose role is to fill the DNA gaps arising in the base excision repair pathway. Mutations in Polβ can lead to cancer, neurodegenerative diseases, or premature aging. Many single-nucleotide polymorphisms have been identified in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.