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Article

The DNA polymerase lambda is required for the repair of non-compatible DNA double strand breaks by NHEJ in mammalian cells.

Nucleic acids research - 1 Jan 2006

Capp Jean-Pascal, Boudsocq François, Bertrand Pascale, Laroche-Clary Audrey, Pourquier Philippe, Lopez Bernard S, Cazaux Christophe, Hoffmann Jean-Sébastien, Canitrot Yvan

Abstract excerpt

DNA polymerase lambda (pollambda) is a recently identified DNA polymerase whose cellular function remains elusive. Here we show, that pollambda participates at the molecular level in a chromosomal context, in the repair of DNA double strand breaks (DSB) via non-homologous end joining (NHEJ) in mammalian cells. The expression of a catalytically inactive form of pollambda (pollambdaDN) decreases the frequency of...

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Identifiers

PMID: 16738138
DOI: 10.1093/nar/gkl380
PMCID: PMC1474058

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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