Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA polymerases and human diseases.

Radiation research - 1 Nov 2006

Sweasy Joann B, Lauper Julia M, Eckert Kristin A

Abstract excerpt

DNA polymerases function in DNA replication, repair, recombination and translesion synthesis. Currently, 15 DNA polymerase genes have been identified in human cells, belonging to four distinct families. In this review, we briefly describe the biochemical activities and known cellular roles of each DNA polymerase. Our major focus is on the phenotypic consequences of mutation or ablation of individual DNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Directed DNA Polymerase
Share to Genetic Predisposition to Disease
Share to Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Neoplasms

Share to Neurodegenerative Diseases

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 17067213
DOI: 10.1667/RR0706.1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA polymerases and human diseases.PMID 17067213Read ↗

Mouse models of DNA polymerases.Semantic proximity Read ↗

Association of Mutations in Replicative DNA Polymerase Genes with Human Disease: Possible Application of Drosophila Models for Studies.Semantic proximity Read ↗

Polymerase ε1 mutation in a human syndrome with facial dysmorphism, immunodeficiency, livedo, and short stature (“FILS syndrome”)Semantic proximity Read ↗

DNA polymerases and cancerSemantic proximity Read ↗

Replication DNA polymerases, genome instability and cancer therapiesSemantic proximity Read ↗

Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy.Semantic proximity Read ↗

The Role of Natural Polymorphic Variants of DNA Polymerase β in DNA RepairSemantic proximity Read ↗

Replication proteins and human disease.Semantic proximity Read ↗

Human DNA repair genesSemantic proximity Read ↗

Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis.Semantic proximity Read ↗

<i>In vivo</i> and <i>in vitro</i> mechanistic characterization of a clinically relevant PolγA mutationSemantic proximity Read ↗

Considering the cancer consequences of altered DNA polymerase functionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.