Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The HLA-DR4-associated DQw8 allele is confined to HLA-DR3/DR4 heterozygous type I (insulin-dependent) diabetics.

Tissue antigens - 1 Aug 1990

Boehm B O, Schifferdecker E, Rosak C, Kuehnl P, Driesel A J, Schöffling K

Abstract excerpt

The HLA-DR4 specificity revealed a relative risk of 8.5 (chi 2 = 99.6; p less than 0.0001) when 193 type I diabetics were compared to 305 controls. Prevalence of the HLA-DR4-associated DQ types, i.e. DQw7 and DQw8, were determined, using a restriction fragment length polymorphism (RFLP) typing th...

Topics

Alleles
Diabetes Mellitus, Type 1
Germany
HLA-DQ Antigens
HLA-DR3 Antigen
HLA-DR4 Antigen
Heterozygote
Humans
Polymorphism, Restriction Fragment Length

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1980162
DOI: 10.1111/j.1399-0039.1990.tb01804.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1980162-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The HLA-DR4-associated DQw8 allele is confined to HLA-DR3/DR4 heterozygous type I (insulin-dependent) diabetics.PMID 1980162Read ↗

HLA class II-associated predisposition to insulin-dependent diabetes mellitus in a Polish population.Semantic proximity Read ↗

HLA-DQ primarily confers protection and HLA-DR susceptibility in type I (insulin-dependent) diabetes studied in population-based affected families and controls.Semantic proximity Read ↗

Insulin-dependent diabetes mellitus in non-DR3/non-DR4 subjects.Semantic proximity Read ↗

HLA-DR and -DQ associations with insulin-dependent diabetes mellitus in a population of Turkey.Semantic proximity Read ↗

Heterogeneity of HLA genetic factors in IDDM susceptibility.Semantic proximity Read ↗

HLA-DRB1*0401 is associated with susceptibility to insulin-dependent diabetes mellitus independently of the DQB1 locus.Semantic proximity Read ↗

Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus.Semantic proximity Read ↗

HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican-American families.Semantic proximity Read ↗

DNA polymorphism analysis of HLA class II genes in unrelated children and in first-degree relatives with type I diabetes.Semantic proximity Read ↗

HLA-DP, -DQ and -DR RFLP types in south Indian insulin-dependent diabetes mellitus patients.Semantic proximity Read ↗

Comparison between HLA-DRB and DQ DNA sequences and classic serological markers as type 1 (insulin-dependent) diabetes mellitus predictive risk markers in the Spanish population.Semantic proximity Read ↗

The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.