Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The HLA-DR4-associated DQw8 allele is confined to HLA-DR3/DR4 heterozygous type I (insulin-dependent) diabetics.

Tissue antigens - 1 Aug 1990

Boehm B O, Schifferdecker E, Rosak C, Kuehnl P, Driesel A J, Schöffling K

Abstract excerpt

The HLA-DR4 specificity revealed a relative risk of 8.5 (chi 2 = 99.6; p less than 0.0001) when 193 type I diabetics were compared to 305 controls. Prevalence of the HLA-DR4-associated DQ types, i.e. DQw7 and DQw8, were determined, using a restriction fragment length polymorphism (RFLP) typing that combines the probe/enzyme combinations DQB/Taq I and DQB/Bam HI. The HLA-DQw8 specificity was confined to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Diabetes Mellitus, Type 1
Share to Germany

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Heterozygote

Share to HLA-DQ Antigens

Share to HLA-DR3 Antigen

Share to HLA-DR4 Antigen

Share to Polymorphism, Restriction Fragment Length

Source

Identifiers

PMID: 1980162
DOI: 10.1111/j.1399-0039.1990.tb01804.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The HLA-DR4-associated DQw8 allele is confined to HLA-DR3/DR4 heterozygous type I (insulin-dependent) diabetics.PMID 1980162Read ↗

HLA class II-associated predisposition to insulin-dependent diabetes mellitus in a Polish population.Semantic proximity Read ↗

HLA-DQ primarily confers protection and HLA-DR susceptibility in type I (insulin-dependent) diabetes studied in population-based affected families and controls.Semantic proximity Read ↗

Insulin-dependent diabetes mellitus in non-DR3/non-DR4 subjects.Semantic proximity Read ↗

HLA-DR and -DQ associations with insulin-dependent diabetes mellitus in a population of Turkey.Semantic proximity Read ↗

Heterogeneity of HLA genetic factors in IDDM susceptibility.Semantic proximity Read ↗

HLA-DRB1*0401 is associated with susceptibility to insulin-dependent diabetes mellitus independently of the DQB1 locus.Semantic proximity Read ↗

Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus.Semantic proximity Read ↗

HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican-American families.Semantic proximity Read ↗

DNA polymorphism analysis of HLA class II genes in unrelated children and in first-degree relatives with type I diabetes.Semantic proximity Read ↗

HLA-DP, -DQ and -DR RFLP types in south Indian insulin-dependent diabetes mellitus patients.Semantic proximity Read ↗

Comparison between HLA-DRB and DQ DNA sequences and classic serological markers as type 1 (insulin-dependent) diabetes mellitus predictive risk markers in the Spanish population.Semantic proximity Read ↗

The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.