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Article

The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families.

American journal of human genetics - 1 Nov 1996

Noble J A, Valdes A M, Cook M, Klitz W, Thomson G, Erlich H A

Abstract excerpt

We report here our analysis of HLA class II alleles in 180 Caucasian nuclear families with at least two children with insulin-dependent diabetes mellitus (IDDM). DRB1, DQA1, DQB1, and DPB1 genotypes were determined with PCR/sequence-specific oligonucleotide probe typing methods. The data allowed unambiguous determination of four-locus haplotypes in all but three of the families. Consistent with other studies, our...

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Identifiers

PMID: 8900244
PMCID: PMC1914851

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families.PMID 8900244Read ↗

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HLA class II-associated predisposition to insulin-dependent diabetes mellitus in a Polish population.Semantic proximity Read ↗

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Deciphering the Genetic Landscape: Exploring the Relationship Between HLA-DQA1, HLA-DQB1, and HLA-DRB1 Genes in Diabetes MellitusSemantic proximity Read ↗

The HLA class II locus DPB1 can influence susceptibility to type 1 diabetes.Semantic proximity Read ↗

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Analysis of HLA-DQA1 and -DQB1 genes in Mexican Americans with insulin-dependent diabetes mellitus.Semantic proximity Read ↗

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