Article
HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican-American families.
Nature genetics - 1 Apr 1993
Erlich H A, Zeidler A, Chang J, Shaw S, Raffel L J, Klitz W, Beshkov Y, Costin G, Pressman S, Bugawan T
Abstract excerpt
The role of HLA class II alleles in genetic predisposition to insulin dependent diabetes mellitus (IDDM) was examined by PCR/oligonucleotide probe typing of 42 Mexican-American IDDM families derived from Hispanic Caucasians and Native Americans. All high risk haplotypes (HLA-DR3 and DR4) were of...
Topics
- Alleles
- Diabetes Mellitus, Type 1
- Gene Frequency
- Genetic Predisposition to Disease
- HLA-D Antigens
- HLA-DQ Antigens
- HLA-DR Antigens
- Haplotypes
- Histocompatibility Antigens Class II
- Humans
- Immunity, Innate
- Mexican Americans
- Mexico
- Pedigree