HLA-DRB1*0401 is associated with susceptibility to insulin-dependent diabetes mellitus independently of the DQB1 locus.

doi:10.1111/j.1744-313x.1995.tb00245.x

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Article

HLA-DRB1*0401 is associated with susceptibility to insulin-dependent diabetes mellitus independently of the DQB1 locus.

European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Aug 1995

Tait B D, Drummond B P, Varney M D, Harrison L C

Abstract excerpt

The distribution of DRB1*04 alleles and DRB1/DQB1 haplotypes was analysed in 57 DR4+ caucasoid subjects with insulin-dependent diabetes mellitus (IDDM) and 96 DR4+ healthy controls selected on the basis of DR serology, and the findings were analysed in relation to age at diagnosis of IDDM. DNA sa...

Topics

Adolescent
Adult
Alleles
Autoimmune Diseases
Child
Child, Preschool
Diabetes Mellitus, Type 1
Disease Susceptibility
Genes, MHC Class II
Genetic Predisposition to Disease
HLA-DQ Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HLA-DQ beta-Chains

HLA-DR Antigens

HLA-DR4 Antigen

HLA-DRB1 Chains

Haplotypes

Humans

White People

Source

Open in PubMed

Identifiers

PMID: 7495781
DOI: 10.1111/j.1744-313x.1995.tb00245.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7495781-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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HLA-DRB1*0401 is associated with susceptibility to insulin-dependent diabetes mellitus independently of the DQB1 locus.PMID 7495781Read ↗

Age-dependent HLA genetic heterogeneity of type 1 insulin-dependent diabetes mellitus.Semantic proximity Read ↗

The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families.Semantic proximity Read ↗

HLA class II-associated predisposition to insulin-dependent diabetes mellitus in a Polish population.Semantic proximity Read ↗

Distribution of HLA-DRB1, -DQA1 and -DQB1 alleles and DQA1-DQB1 genotypes among Norwegian patients with insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Contribution of DRB1*04 variants to predisposition to or protection from insulin dependent diabetes mellitus is independent of dq.Semantic proximity Read ↗

Insulin-dependent diabetes mellitus in non-DR3/non-DR4 subjects.Semantic proximity Read ↗

HLA-DR and -DQ associations with insulin-dependent diabetes mellitus in a population of Turkey.Semantic proximity Read ↗

DRB1*0403 protects against IDDM in Caucasians with the high-risk heterozygous DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 genotype. Belgian Diabetes Registry.Semantic proximity Read ↗

HLA-DQ primarily confers protection and HLA-DR susceptibility in type I (insulin-dependent) diabetes studied in population-based affected families and controls.Semantic proximity Read ↗

Associations of MHC class II alleles with insulin-dependent diabetes mellitus (IDDM) in patients from North India.Semantic proximity Read ↗

Ethnic differences in the associations between the HLA-DRB1*04 subtypes and type 1 diabetes.Semantic proximity Read ↗

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