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Article

Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus.

The New England journal of medicine - 28 Jun 1990

Baisch J M, Weeks T, Giles R, Hoover M, Stastny P, Capra J D

Abstract excerpt

There is evidence that certain alleles at the HLA-DQ locus are correlated with susceptibility to insulin-dependent diabetes mellitus (IDDM) and in particular that DQ beta-chain alleles containing aspartic acid at position 57 are protective. The availability of a large group of patients with IDDM enabled us to assess the role of HLA-DQ alleles in susceptibility to the disease in order to confirm and extend recent...

Topics

Adult
Alleles
Base Sequence
Diabetes Mellitus, Type 1
Disease Susceptibility
Female
Genotype
HLA-DQ Antigens
HLA-DQ beta-Chains
Humans
Male
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nucleotide Mapping

Polymerase Chain Reaction

Source

Identifiers

PMID: 2348836
DOI: 10.1056/NEJM199006283222602

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2348836-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Related research

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Click a neighbor to travelStep 1 · 12 closest

Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus.PMID 2348836Read ↗

HLA-DQ beta sequence polymorphism and genetic susceptibility to IDDM.Semantic proximity Read ↗

Analysis of HLA genotypes and susceptibility to insulin-dependent diabetes mellitus: HLA-DQ alpha complements HLA-DQ beta.Semantic proximity Read ↗

HLA-DQA and DQB alleles contribute to susceptibility to insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Genetic analysis of HLA class II alleles and susceptibility to type 1 (insulin-dependent) diabetes mellitus in Japanese subjects.Semantic proximity Read ↗

Analysis of HLA genotypes and susceptibility to insulin-dependent diabetes mellitus: association maps telomeric to HLA-DP.Semantic proximity Read ↗

Analysis of HLA-DQA1 and -DQB1 genes in Mexican Americans with insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Implication of specific DQB1 alleles in genetic susceptibility and resistance by identification of IDDM siblings with novel HLA-DQB1 allele and unusual DR2 and DR1 haplotypes.Semantic proximity Read ↗

HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus.Semantic proximity Read ↗

The complex interplay of the DQB1 and DQA1 loci in the generation of the susceptible and protective phenotype for insulin-dependent diabetes mellitus.Semantic proximity Read ↗

HLA-DQB1 alleles and absence of Asp 57 as susceptibility factors of IDDM in Finland.Semantic proximity Read ↗

HLA-DQB 1 codon 57 and genetic susceptibility to type 1 (insulin-dependent) diabetes mellitus in French children.Semantic proximity Read ↗

Improved risk assessment for insulin-dependent diabetes mellitus by analysis of amino acids in HLA-DQ and DRB1 loci.Semantic proximity Read ↗

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