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Article

Structure-activity analysis of semisynthetic nucleosomes: mechanistic insights into the stimulation of Dot1L by ubiquitylated histone H2B.

ACS chemical biology - 20 Nov 2009

McGinty Robert K, Köhn Maja, Chatterjee Champak, Chiang Kyle P, Pratt Matthew R, Muir Tom W

Abstract excerpt

Post-translational modification of histones plays an integral role in regulation of genomic expression through modulation of chromatin structure and function. Chemical preparations of histones bearing these modifications allows for comprehensive in vitro mechanistic investigation into their actio...

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Identifiers

PMID: 19799466
DOI: 10.1021/cb9002255
PMCID: PMC2785503

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19799466-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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