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Article

Histone monoubiquitylation position determines specificity and direction of enzymatic cross-talk with histone methyltransferases Dot1L and PRC2.

The Journal of biological chemistry - 6 Jul 2012

Whitcomb Sarah J, Fierz Beat, McGinty Robert K, Holt Matthew, Ito Takashi, Muir Tom W, Allis C David

Abstract excerpt

It is well established that chromatin is a destination for signal transduction, affecting many DNA-templated processes. Histone proteins in particular are extensively post-translationally modified. We are interested in how the complex repertoire of histone modifications is coordinately regulated to generate meaningful combinations of "marks" at physiologically relevant genomic locations. One important mechanism...

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Identifiers

PMID: 22619169
DOI: 10.1074/jbc.M112.361824
PMCID: PMC3390646

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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