Article

The mechanism of cross-talk between histone H2B ubiquitination and H3 methylation by Dot1L

2018-12-19

Abstract excerpt

Methylation of histone H3, lysine 79 (H3K79), by Dot1L is a hallmark of actively transcribed genes that depends on monoubiquitination of H2B at lysine 120 (H2B-Ub), and is a well-characterized example of histone modification cross-talk that is conserved from yeast to humans. The mechanism by which H2B-Ub stimulates Dot1L to methylate the relatively inaccessible histone core H3K79 residue is unknown. The 3.0 Å reso...

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Literature Corpus work: 0c78c761-5d11-5d3a-82e7-9729ef6f3580
DOI: 10.1101/501098

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