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Article

Live-Cell Epigenome Manipulation by Synthetic Histone Acylation Catalyst System

2020-04-26

Abstract excerpt

Chemical modifications of histones play a pivotal role in the epigenome and regulation of gene expression, and their abnormality is tightly linked to numerous disease states in humans. Therefore, chemical tools to manipulate epigenome hold promise for both therapy and the elucidation of epigenetic mechanisms. We previously developed the chemical catalyst LANA-DSH, which binds to nucleosomes via a LANA peptide liga...

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Literature Corpus work
cd34bfc8-c613-56c6-ac43-2ddabd34bbbb
DOI
10.26434/chemrxiv.12186531.v1
Open publication

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Live-Cell Epigenome Manipulation by Synthetic Histone Acylation Catalyst SystemDOI 10.26434/chemrxiv.12186531.v1
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