Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transgene-induced mutation of the murine steel locus.

Proceedings of the National Academy of Sciences of the United States of America - 1 Dec 1990

Keller S A, Liptay S, Hajra A, Meisler M H

Abstract excerpt

The product of the steel locus is essential for normal development of three distinct populations of stem cells--the neural crest-derived melanoblasts, germ cells, and blood cell precursors. Many mutant alleles at steel are lethal in homozygotes and produce coat color dilution in heterozygotes. We have identified a transgenic mouse with diluted pigmentation that closely resembles that of steel heterozygotes. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mutation
Share to Phenotype
Share to Genotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosome Mapping

Share to Genetic Linkage

Share to Polymorphism, Restriction Fragment Length

Source

Open in PubMed Open full text

Identifiers

PMID: 1979872
DOI: 10.1073/pnas.87.24.10019
PMCID: PMC55306

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transgene-induced mutation of the murine steel locus.PMID 1979872Read ↗

Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles.Semantic proximity Read ↗

Extracellular matrix from normal but not Steel mutant mice enhances melanogenesis in cultured mouse neural crest cells.Semantic proximity Read ↗

DNA rearrangements located over 100 kb 5' of the Steel (Sl)-coding region in Steel-panda and Steel-contrasted mice deregulate Sl expression and cause female sterility by disrupting ovarian follicle development.Semantic proximity Read ↗

The murine W/c-kit and Steel loci and the control of hematopoiesis.Semantic proximity Read ↗

Mouse coat color mutations: from fancy mice to functional genomics.Semantic proximity Read ↗

The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis.Semantic proximity Read ↗

A rare complex DNA rearrangement in the murine Steel gene results in exon duplication and a lethal phenotype.Semantic proximity Read ↗

Contiguous patterns of c-kit and steel expression: analysis of mutations at the W and Sl loci.Semantic proximity Read ↗

Effects of spontaneous KitlSteel mutations on survival and red blood cells of mice.Semantic proximity Read ↗

Soluble and cell-bound forms of steel factor activity play distinct roles in melanocyte precursor dispersal and survival on the lateral neural crest migration pathway.Semantic proximity Read ↗

W-sash affects positive and negative elements controlling c-kit expression: ectopic c-kit expression at sites of kit-ligand expression affects melanogenesis.Semantic proximity Read ↗

Spotlight on spotted mice: a review of white spotting mouse mutants and associated human pigmentation disorders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.