Article
Transgene-induced mutation of the murine steel locus.
Proceedings of the National Academy of Sciences of the United States of America - 1 Dec 1990
Keller S A, Liptay S, Hajra A, Meisler M H
Abstract excerpt
The product of the steel locus is essential for normal development of three distinct populations of stem cells--the neural crest-derived melanoblasts, germ cells, and blood cell precursors. Many mutant alleles at steel are lethal in homozygotes and produce coat color dilution in heterozygotes. We have identified a transgenic mouse with diluted pigmentation that closely resembles that of steel heterozygotes. We...
Topics
- Animals
- Blotting, Southern
- Chromosome Mapping
- DNA
- Genes, Recessive
- Genetic Carrier Screening
- Genetic Linkage
- Genotype
- Hair Color
- Male
- Mice
- Mice, Transgenic