Contiguous patterns of c-kit and steel expression: analysis of mutations at the W and Sl loci.

Abstract excerpt

Mutations in either the dominant white-spotting (W) or Steel (Sl) loci of the mouse lead to coat color, primordial germ cell and hematopoietic defects. Consistent with the cell autonomous and microenvironmental nature of W and Sl mutations, respectively, it has recently been shown that W encodes the c-kit receptor tyrosine kinase while Sl encodes a ligand for this receptor. Previous in situ hybridization analysis...

Topics

• Animals
• Brain
• Gene Expression
• Genes
• Gonads
• Hematopoietic Stem Cells
• Melanocytes
• Mice
• Mice, Mutant Strains
• Molecular Probe Techniques
• Mutation
• Transduction, Genetic