Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles.

doi:10.1016/0092-8674(90)90298-s

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Article

Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles.

Cell - 5 Oct 1990

Copeland N G, Gilbert D J, Cho B C, Donovan P J, Jenkins N A, Cosman D, Anderson D, Lyman S D, Williams D E

Abstract excerpt

Many spontaneous, chemical-induced, and radiation-induced dominant white spotting (W) and steel (Sl) mutations have been identified in the mouse. W and Sl mutations have similar phenotypic effects including deficiencies in pigment cells, germ cells, and blood cells, Numerous studies have suggested that W acts within the affected cell while Sl instead exerts its effects in the extracellular environment. Recent...

Topics

Alleles
Amino Acid Sequence
Animals
Base Sequence
Blotting, Southern
Chromosome Deletion
Chromosome Mapping
Crosses, Genetic
DNA
Female
Genes, Dominant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Linkage

Hematopoietic Cell Growth Factors

Male

Mice

Mice, Inbred C57BL

Molecular Sequence Data

Mutation

Source

Open in PubMed

Identifiers

PMID: 1698554
DOI: 10.1016/0092-8674(90)90298-s

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1698554-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles.PMID 1698554Read ↗

The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus.Semantic proximity Read ↗

Characterization of the gene-product of the Steel locus.Semantic proximity Read ↗

Steel factor and c-kit protooncogene: genetic lessons in signal transduction.Semantic proximity Read ↗

The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor.Semantic proximity Read ↗

Transgene-induced mutation of the murine steel locus.Semantic proximity Read ↗

A rare complex DNA rearrangement in the murine Steel gene results in exon duplication and a lethal phenotype.Semantic proximity Read ↗

Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains.Semantic proximity Read ↗

A point mutation in the catalytic domain of c-kit induces growth factor independence, tumorigenicity, and differentiation of mast cellsSemantic proximity Read ↗

Mouse hematopoietic stem cells and the interaction of c-kit receptor and steel factor.Semantic proximity Read ↗

Loss of the transmembrane but not the soluble kit ligand isoform increases testicular germ cell tumor susceptibility in mice.Semantic proximity Read ↗

The kit ligand encoded at the murine Steel locus: a pleiotropic growth and differentiation factor.Semantic proximity Read ↗

Cre/loxP-based mouse models of mast cell deficiency and mast cell-specific gene inactivation.Semantic proximity Read ↗

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