DNA rearrangements located over 100 kb 5' of the Steel (Sl)-coding region in Steel-panda and Steel-contrasted mice deregulate Sl expression and cause female sterility by disrupting ovarian follicle development.

doi:10.1101/gad.9.4.455

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Article

DNA rearrangements located over 100 kb 5' of the Steel (Sl)-coding region in Steel-panda and Steel-contrasted mice deregulate Sl expression and cause female sterility by disrupting ovarian follicle development.

Genes & development - 15 Feb 1995

Bedell M A, Brannan C I, Evans E P, Copeland N G, Jenkins N A, Donovan P J

Abstract excerpt

The Steel (Sl) locus is essential for the development of germ cells, hematopoietic cells, and melanocytes and encodes a growth factor (Mgf) that is the ligand for c-kit, a receptor tyrosine kinase encoded by the W locus. We have identified the molecular and germ cell defects in two mutant Sl alleles, Steel-panda (Slpan) and Steel-contrasted (Slcon), that cause sterility only in females. Unexpectedly, both mutant...

Topics

Animals
Chromosome Inversion
Chromosome Mapping
Crosses, Genetic
Female
Gene Expression Regulation
Gene Rearrangement
Genetic Complementation Test
Genitalia, Female
Hematopoietic Cell Growth Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Histocytochemistry

In Situ Hybridization

Infertility, Female

Male

Mice

Mice, Inbred C3H

Mice, Inbred C57BL

Mutation

Source

Open in PubMed

Identifiers

PMID: 7533739
DOI: 10.1101/gad.9.4.455

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7533739-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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DNA rearrangements located over 100 kb 5' of the Steel (Sl)-coding region in Steel-panda and Steel-contrasted mice deregulate Sl expression and cause female sterility by disrupting ovarian follicle development.PMID 7533739Read ↗

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