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Article

A rare complex DNA rearrangement in the murine Steel gene results in exon duplication and a lethal phenotype.

Blood - 15 Nov 2003

Chandra Saurabh, Kapur Reuben, Chuzhanova Nadia, Summey Victoria, Prentice David, Barker Jane, Cooper David N, Williams David A

Abstract excerpt

Kit ligand (Kitl), encoded by the Steel (Sl) locus, plays an essential role in hematopoiesis, gametogenesis, and melanogenesis during both embryonic and adult life. We have characterized a new spontaneous mutant of the Sl locus in mice designated KitlSl-20J that arose in the breeding colony at Jackson Laboratories. Heterozygous KitlSl-20J mice display a white belly spot and intercrossing results in an embryonic...

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Identifiers

PMID: 12881302
DOI: 10.1182/blood-2003-05-1468

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A rare complex DNA rearrangement in the murine Steel gene results in exon duplication and a lethal phenotype.PMID 12881302Read ↗

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Steel factor and c-kit protooncogene: genetic lessons in signal transduction.Semantic proximity Read ↗

DNA rearrangements located over 100 kb 5' of the Steel (Sl)-coding region in Steel-panda and Steel-contrasted mice deregulate Sl expression and cause female sterility by disrupting ovarian follicle development.Semantic proximity Read ↗

Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant.Semantic proximity Read ↗

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