Article
The murine W/c-kit and Steel loci and the control of hematopoiesis.
Seminars in hematology - 1 Apr 1991
Bernstein A, Forrester L, Reith A D, Dubreuil P, Rottapel R
Abstract excerpt
The experiments summarized here indicate that germ-line mutations in either the c-kit receptor tyrosine kinase (W mutants) or its ligand (Sl) lead to profound and pleiotropic developmental defects, including abnormalities within the hematopoietic system. These observations parallel findings in other developmental systems, notably the fruit fly Drosophila, that receptor tyrosine kinases play key roles in the...
Topics
- Animals
- Cells, Cultured
- Hematopoiesis
- Mice
- Mice, Mutant Strains
- Mutation
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-kit
- Proto-Oncogenes