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Article

Association of HTRA1 promoter polymorphism with spinal disc degeneration in Japanese women.

Journal of bone and mineral metabolism - 1 Mar 2010

Urano Tomohiko, Narusawa Ken'ichiro, Kobayashi Satomi, Shiraki Masataka, Horie-Inoue Kuniko, Sasaki Noriko, Hosoi Takayuki, Ouchi Yasuyoshi, Nakamura Toshitaka, Inoue Satoshi

Abstract excerpt

HTRA1 (high-temperature requirement A1) has been implicated in the modulation of various disease pathologies. HTRA1 expression is upregulated in osteoarthritic joints, suggesting that it may contribute to the development of this debilitating disease. Moreover, recent reports have shown that the r...

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Source

Identifiers

PMID: 19798546
DOI: 10.1007/s00774-009-0124-0

Genes

HTRA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19798546-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Association of HTRA1 promoter polymorphism with spinal disc degeneration in Japanese women.PMID 19798546Read ↗

Association of the HTRA1 gene variant with age-related macular degeneration in the Japanese population.Semantic proximity Read ↗

HTRA1 rs11200638 variant and AMD risk from a comprehensive analysis about 15,316 subjects.Semantic proximity Read ↗

Polymorphism rs11200638 enhanced HtrA1 responsiveness and expression are associated with age-related macular degeneration.Semantic proximity Read ↗

HTRA1 promoter polymorphism predisposes Japanese to age-related macular degeneration.Semantic proximity Read ↗

Meta-analysis of the association of the HTRA1 polymorphisms with the risk of age-related macular degeneration.Semantic proximity Read ↗

HTRA1 promoter polymorphism and risk of age-related macular degeneration: a meta-analysis.Semantic proximity Read ↗

Human HtrA1 in the archived eyes with age-related macular degeneration.Semantic proximity Read ↗

HTRA1 variant increases risk to neovascular age-related macular degeneration in Chinese population.Semantic proximity Read ↗

High-temperature requirement factor A1 rs11200638 polymorphism and age-related macular degenerative from a comprehensive analysis about 15316 subjectsSemantic proximity Read ↗

Association of HTRA1 rs11200638 with age-related macular degeneration (AMD) in Brazilian patients.Semantic proximity Read ↗

An intergenic region between the tagSNP rs3793917 and rs11200638 in the HTRA1 gene indicates association with age-related macular degeneration.Semantic proximity Read ↗

Further mapping of 10q26 supports strong association of HTRA1 polymorphisms with age-related macular degeneration.Semantic proximity Read ↗

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