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Article

An intergenic region between the tagSNP rs3793917 and rs11200638 in the HTRA1 gene indicates association with age-related macular degeneration.

Investigative ophthalmology & visual science - 1 Oct 2010

Richardson Andrea J, Islam F M Amirul, Aung Khin Zaw, Guymer Robyn H, Baird Paul N

Abstract excerpt

PURPOSE: There is still a debate as to whether the LOC387715 or HTRA1 genes represent the key significant association identified with age-related macular degeneration (AMD) on the long arm of chromosome 10, region 26. METHODS: An Australian patient cohort was genotyped by using tagged single nucl...

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Source

Identifiers

PMID: 20445115
DOI: 10.1167/iovs.09-5114

Genes

HTRA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20445115-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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An intergenic region between the tagSNP rs3793917 and rs11200638 in the HTRA1 gene indicates association with age-related macular degeneration.PMID 20445115Read ↗

Further mapping of 10q26 supports strong association of HTRA1 polymorphisms with age-related macular degeneration.Semantic proximity Read ↗

Variants in the 10q26 gene cluster (LOC387715 and HTRA1) exhibit enhanced risk of age-related macular degeneration along with CFH in Indian patients.Semantic proximity Read ↗

HTRA1 variants in exudative age-related macular degeneration and interactions with smoking and CFH.Semantic proximity Read ↗

HTRA1 rs11200638 variant and AMD risk from a comprehensive analysis about 15,316 subjects.Semantic proximity Read ↗

Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration.Semantic proximity Read ↗

LOC387715/HTRA1 gene polymorphisms and susceptibility to age-related macular degeneration: A HuGE review and meta-analysis.Semantic proximity Read ↗

A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration.Semantic proximity Read ↗

Association of HTRA1 rs11200638 with age-related macular degeneration (AMD) in Brazilian patients.Semantic proximity Read ↗

Analysis of six genetic risk factors highly associated with AMD in the region surrounding ARMS2 and HTRA1 on chromosome 10, region q26.Semantic proximity Read ↗

The LOC387715 polymorphism and age-related macular degeneration: replication in three case-control samples.Semantic proximity Read ↗

Meta-analysis of the association of the HTRA1 polymorphisms with the risk of age-related macular degeneration.Semantic proximity Read ↗

Human HtrA1 in the archived eyes with age-related macular degeneration.Semantic proximity Read ↗

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