Further mapping of 10q26 supports strong association of HTRA1 polymorphisms with age-related macular degeneration.

doi:10.1016/j.visres.2007.10.022

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Article

Further mapping of 10q26 supports strong association of HTRA1 polymorphisms with age-related macular degeneration.

Vision research - 1 Feb 2008

Gibbs Daniel, Yang Zhenglin, Constantine Ryan, Ma Xiang, Camp Nicola J, Yang Xian, Chen Hayou, Jorgenson Adam, Hau Vincent, Dewan Andrew, Zeng Jiexi, Harmon Jennifer, Buehler Jeanette, Brand John M, Hoh Josephine, Cameron D Joshua, Dixit Manjusha, Tong Zongzhong, Zhang Kang

Abstract excerpt

Age-related macular degeneration (AMD) is a complex disorder with genetic and environmental influences. The genetic influences affecting AMD are not well understood and few genes have been consistently implicated and replicated for this disease. A polymorphism (rs11200638) in a transcription factor binding site of the HTRA1 gene has been described, in previous reports, as being most significantly associated with...

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PMID: 18207215
DOI: 10.1016/j.visres.2007.10.022

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HTRA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Further mapping of 10q26 supports strong association of HTRA1 polymorphisms with age-related macular degeneration.PMID 18207215Read ↗

A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration.Semantic proximity Read ↗

Analysis of six genetic risk factors highly associated with AMD in the region surrounding ARMS2 and HTRA1 on chromosome 10, region q26.Semantic proximity Read ↗

Association of HTRA1 rs11200638 with age-related macular degeneration (AMD) in Brazilian patients.Semantic proximity Read ↗

An intergenic region between the tagSNP rs3793917 and rs11200638 in the HTRA1 gene indicates association with age-related macular degeneration.Semantic proximity Read ↗

Current Views on Chr10q26 Contribution to Age-Related Macular Degeneration.Semantic proximity Read ↗

Specific correlation between the major chromosome 10q26 haplotype conferring risk for age-related macular degeneration and the expression of HTRA1.Semantic proximity Read ↗

Chromosome 10q26 locus and age-related macular degeneration: a progress update.Semantic proximity Read ↗

HTRA1 rs11200638 variant and AMD risk from a comprehensive analysis about 15,316 subjects.Semantic proximity Read ↗

10q26 - The enigma in age-related macular degeneration.Semantic proximity Read ↗

A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration.Semantic proximity Read ↗

HTRA1 promoter polymorphism predisposes Japanese to age-related macular degeneration.Semantic proximity Read ↗

Variants at chromosome 10q26 locus and the expression of HTRA1 in the retina.Semantic proximity Read ↗

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