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Article

Polymorphism rs11200638 enhanced HtrA1 responsiveness and expression are associated with age-related macular degeneration.

Eye (London, England) - 1 Aug 2022

He Fen, Li Xiaohong, Cai Suping, Lu Lan, Zhang Tong, Yang Ming, Fan Ning, Wang Xizhen, Liu Xuyang

Abstract excerpt

OBJECTIVES: To investigate the role of polymorphism rs11200638 of high-temperature requirement factor A-1 (HtrA1) gene in the pathogenesis of age-related macular degeneration (AMD). METHODS: Cultured adult retinal pigment epithelial cells (ARPE-19) expressing HtrA1 gene were treated with H2O2 or lipopolysaccharides (LPS) and analysed using western blot and quantitative polymerase chain reaction to illustrate the...

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Identifiers

PMID: 34326497
DOI: 10.1038/s41433-021-01706-8
PMCID: PMC9307815

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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