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BCL6 and the Notch pathway: a signaling axis leading to a novel druggable biotarget in triple negative breast cancer

31 Mar 2022

Abstract excerpt

BACKGROUND: The transcriptional repressor B-cell lymphoma 6 (BCL6) is dysregulated in several neoplasms, but its role in triple negative breast cancer (TNBC), a highly aggressive subtype which lacks effective treatment, is unclear. The presence of intratumoral cancer stem cells (CSCs) is a main cause of tumor relapse. The Notch signaling pathway is crucial for regulating CSC self-renewal and promoting breast...

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PMID: 35357654
DOI: 10.1007/s13402-022-00663-y

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