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Article

Alterations of the Notch pathway in lung cancer.

Proceedings of the National Academy of Sciences of the United States of America - 29 Dec 2009

Westhoff Britta, Colaluca Ivan N, D'Ario Giovanni, Donzelli Maddalena, Tosoni Daniela, Volorio Sara, Pelosi Giuseppe, Spaggiari Lorenzo, Mazzarol Giovanni, Viale Giuseppe, Pece Salvatore, Di Fiore Pier Paolo

Abstract excerpt

Notch signaling regulates cell specification and homeostasis of stem cell compartments, and it is counteracted by the cell fate determinant Numb. Both Numb and Notch have been implicated in human tumors. Here, we show that Notch signaling is altered in approximately one third of non-small-cell lu...

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Source

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Identifiers

PMID: 20007775
DOI: 10.1073/pnas.0907781106
PMCID: PMC2799768

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20007775-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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