Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pre‐clinical validation of a selective anti‐cancer stem cell therapy for Numb‐deficient human breast cancers

15 Mar 2017

Abstract excerpt

The cell fate determinant Numb is frequently downregulated in human breast cancers (BCs), resulting in p53 inactivation and an aggressive disease course. In the mouse mammary gland, Numb/p53 downregulation leads to aberrant tissue morphogenesis, expansion of the stem cell compartment, and emergence of cancer stem cells (CSCs). Strikingly, CSC phenotypes in a Numb-knockout mouse model can be reverted by Numb/p53...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer-related Molecular Pathways
Share to Hedgehog Signaling Pathway Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28298340
DOI: 10.15252/emmm.201606940

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pre‐clinical validation of a selective anti‐cancer stem cell therapy for Numb‐deficient human breast cancersPMID 28298340Read ↗

The Numb/p53 circuitry couples replicative self-renewal and tumor suppression in mammary epithelial cellsSemantic proximity Read ↗

Numb protein expression correlates with a basal-like phenotype and cancer stem cell markers in primary breast cancer.Semantic proximity Read ↗

Numb Regulates Glioma Stem Cell Fate and Growth by Altering Epidermal Growth Factor Receptor and Skp1-Cullin-F-Box Ubiquitin Ligase ActivitySemantic proximity Read ↗

Role of NuMA1 in breast cancer stem cells with implications for combination therapy of PIM1 and autophagy inhibition in triple negative breast cancerSemantic proximity Read ↗

The CRL7 <sup>FBXW8</sup> Complex Controls the Mammary Stem Cell Compartment Through Regulation of NUMB LevelsSemantic proximity Read ↗

ZEB1 confers stem cell-like properties in breast cancer by targeting neurogenin-3Semantic proximity Read ↗

An integrated transcriptional regulatory circuit that reinforces the breast cancer stem cell stateSemantic proximity Read ↗

MiR-4319 Suppress the Malignancy of Triple-Negative Breast Cancer by Regulating Self-Renewal and Tumorigenesis of Stem CellsSemantic proximity Read ↗

BCL6 and the Notch pathway: a signaling axis leading to a novel druggable biotarget in triple negative breast cancerSemantic proximity Read ↗

LNX1 Modulates Notch1 Signaling to Promote Expansion of the Glioma Stem Cell Population During Temozolomide Therapy in GlioblastomaSemantic proximity Read ↗

NEDD4 Plays Roles in the Maintenance of Breast Cancer Stem Cell CharacteristicsSemantic proximity Read ↗

Development of a Fluorescent Reporter System to Delineate Cancer Stem Cells in Triple-Negative Breast CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.