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Article

Alternative Splicing of TCF7L2 Gene in Omental and Subcutaneous Adipose Tissue and Risk of Type 2 Diabetes

29 Sept 2009

Abstract excerpt

BACKGROUND: Single nucleotide polymorphisms (SNPs) rs7903146 and rs12255372 located within TCF7L2 gene have been identified as the strongest common genetic risk factors for development of type 2 diabetes (T2D). We hypothesized that these genetic variants might increase the risk of T2D through regulation of alternative splicing or expression level of TCF7L2 in human adipose tissue. METHODOLOGY/PRINCIPAL FINDINGS:...

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PMID: 19789636
DOI: 10.1371/journal.pone.0007231

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