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Article

Tissue-specific alternative splicing of TCF7L2

14 Jul 2009

Abstract excerpt

Common variants in the transcription factor 7-like 2 (TCF7L2) gene have been identified as the strongest genetic risk factors for type 2 diabetes (T2D). However, the mechanisms by which these non-coding variants increase risk for T2D are not well-established. We used 13 expression assays to survey mRNA expression of multiple TCF7L2 splicing forms in up to 380 samples from eight types of human tissue (pancreas,...

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PMID: 19602480
DOI: 10.1093/hmg/ddp321

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