Article
Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.
The Journal of clinical investigation - 1 Aug 2007
Lyssenko Valeriya, Lupi Roberto, Marchetti Piero, Del Guerra Silvia, Orho-Melander Marju, Almgren Peter, Sjögren Marketa, Ling Charlotte, Eriksson Karl-Fredrik, Lethagen Asa-Linda, Mancarella Rita, Berglund Göran, Tuomi Tiinamaija, Nilsson Peter, Del Prato Stefano, Groop Leif
Abstract excerpt
Genetic variants in the gene encoding for transcription factor-7-like 2 (TCF7L2) have been associated with type 2 diabetes (T2D) and impaired beta cell function, but the mechanisms have remained unknown. We therefore studied prospectively the ability of common variants in TCF7L2 to predict future T2D and explored the mechanisms by which they would do this. Scandinavian subjects followed for up to 22 years were...
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