Article
Genotype and tissue-specific effects on alternative splicing of the transcription factor 7-like 2 gene in humans.
The Journal of clinical endocrinology and metabolism - 1 Mar 2010
Mondal Ashis K, Das Swapan K, Baldini Giulia, Chu Winston S, Sharma Neeraj K, Hackney Oksana G, Zhao Jianhua, Grant Struan F A, Elbein Steven C
Abstract excerpt
CONTEXT: Noncoding single-nucleotide polymorphisms (SNPs) within the TCF7L2 gene are confirmed risk factors for type 2 diabetes, but the mechanism by which they increase risk is unknown. OBJECTIVE: We hypothesized that associated SNPs alter TCF7L2 splicing and that splice forms have altered biolo...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.