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Evaluation of mutagenic mode of action in Big Blue mice fed methylphenidate for 24 weeks.

Mutation research - 1 Jan 2000

Manjanatha Mugimane G, Shelton Sharon D, Dobrovolsky Vasily N, Shaddock Joseph G, McGarrity Lynda G, Twaddle Nathan W, Moore Martha M, Mattison Donald R, Slikker William, Morris Suzanne M

Abstract excerpt

Methylphenidate hydrochloride (MPH), a widely prescribed pediatric drug for attention deficit hyperactivity disorder, induced liver adenocarcinomas in B6C3F1 mice exposed to 500 ppm in feed for 2 years (Dunnick and Hailey (1995) [14]). In order to determine if the induction of liver tumors was by a mutagenic mode of action, groups of male Big Blue (BB) mice (B6C3F1 background) were fed diets containing 50-4000...

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Identifiers

PMID: 19778631
DOI: 10.1016/j.mrgentox.2009.09.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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