Article
Absence of in vivo genotoxicity of 3-monochloropropane-1,2-diol and associated fatty acid esters in a 4-week comprehensive toxicity study using F344 gpt delta rats.
Mutagenesis - 1 Jul 2014
Onami Saeko, Cho Young-Man, Toyoda Takeshi, Horibata Katsuyoshi, Ishii Yuji, Umemura Takashi, Honma Masamitsu, Nohmi Takehiko, Nishikawa Akiyoshi, Ogawa Kumiko
Abstract excerpt
3-Monochloropropane-1,2-diol (3-MCPD) is regarded as a rat renal and testicular carcinogen and has been classified as a possible human carcinogen (group 2B) by International Agency for Research on Cancer. This is potentially of great importance given that esters of this compound have recently found to be generated in many foods and food ingredients as a result of food processing. There have been a few reports...
Topics
- Animals
- Body Weight
- Enzyme Assays
- Esters
- Fatty Acids
- Female
- Humans
- Kidney
- Male
- Membrane Proteins
- Micronucleus Tests