Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

D-Methylphenidate is non-genotoxic in in vitro and in vivo assays.

Mutation research - 9 May 2003

Teo Steve K, San Richard H, Wagner Valentine O, Gudi Ramadevi, Stirling David I, Thomas Steve D, Khetani Vikram D

Abstract excerpt

D-Methylphenidate (dexmethylphenidate; D-MPH) and its racemate D,L-methylphenidate (D,L-MPH) are currently prescribed for the chronic treatment of attention deficit hyperactivity disorder (ADHD) in children. Studies have shown that D-MPH is the pharmacologically active enantiomer for ADHD and is therefore the preferred drug for the treatment of ADHD symptoms. Although studies on the mutagenicity of D,L-MPH have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dose-Response Relationship, Drug
Share to In Vitro Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphoma

Share to Methylphenidate

Share to Micronucleus Tests

Share to Models, Chemical

Share to Mutagens

Share to Stereoisomerism

Source

Identifiers

PMID: 12742508
DOI: 10.1016/s1383-5718(03)00053-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

D-Methylphenidate is non-genotoxic in in vitro and in vivo assays.PMID 12742508Read ↗

Prospective follow-up studies found no chromosomal mutagenicity of methylphenidate therapy in ADHD affected children.Semantic proximity Read ↗

Evaluation of mutagenic mode of action in Big Blue mice fed methylphenidate for 24 weeks.Semantic proximity Read ↗

DNA damage in rats after treatment with methylphenidateSemantic proximity Read ↗

The genetic toxicology of methylphenidate hydrochloride in non-human primates.Semantic proximity Read ↗

Genotoxicity assessment of melamine in the in vivo Pig-a mutation assay and in a standard battery of assays.Semantic proximity Read ↗

Enantiospecific gas chromatographic-mass spectrometric analysis of urinary methylphenidate: implications for phenotyping.Semantic proximity Read ↗

Absence of in vivo genotoxicity of 3-monochloropropane-1,2-diol and associated fatty acid esters in a 4-week comprehensive toxicity study using F344 gpt delta rats.Semantic proximity Read ↗

Review of the genotoxicity of 2-butoxyethanol.Semantic proximity Read ↗

Investigation of the in vitro toxicological properties of the synthetic cannabimimetic drug CP-47,497-C8.Semantic proximity Read ↗

Mutagenicity Assessment of Homologous Series of Methyl Ester Sulphonates (MES) Using the Bacterial Reverse Mutation (Ames) Test.Semantic proximity Read ↗

Biochemical basis for differences in metabolism-dependent genotoxicity by two diazinylpiperazine-based 5-HT2C receptor agonists.Semantic proximity Read ↗

Determination of the impurities in drug products containing montelukast and in silico/in vitro genotoxicological assessments of sulfoxide impurity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.