Article
Comparison of the mutant frequencies and mutation spectra of three non-genotoxic carcinogens, oxazepam, phenobarbital, and Wyeth 14,643, at the lambdacII locus in Big Blue transgenic mice.
Biochemical pharmacology - 15 Sept 2001
Singh V K, Ganesh L, Cunningham M L, Shane B S
Abstract excerpt
Oxazepam (OX), a widely used benzodiazepine anxiolytic, phenobarbital (PHE), a drug used for convulsive disorders, and Wyeth 14,643 (WY; [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid), a hypolipidemic agent, are all hepatocarcinogenic in B6C3F1 mice. They have been classified as "non-genotoxic" carcinogens since they are non-DNA reactive in in vitro assays and are either negative or weakly positive in...
Topics
- Animals
- Carcinogens
- DNA
- Male
- Mice
- Mice, Transgenic
- Mutation
- Oxazepam
- Phenobarbital
- Pyrimidines
- Transcription Factors
- Viral Proteins