Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Organ variation in the mutagenicity of dimethylnitrosamine in Big Blue mice.

Environmental and molecular mutagenesis - 1 Jan 1996

Suzuki T, Itoh T, Hayashi M, Nishikawa Y, Ikezaki S, Furukawa F, Takahashi M, Sofuni T

Abstract excerpt

Organ specificity in the lacI mutant frequency (MF) induced by dimethylnitrosamine (DMN) was analyzed in lung, liver, kidney, bone marrow, urinary bladder, and testis of Big Blue mice. Cell proliferative activity was also analyzed in some of these tissues by immunohistochemical staining of proliferating cell nuclear antigen (PCNA). Clastogenicity of DMN was concomitantly analyzed by the peripheral blood...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins
Share to Cell Division
Share to Escherichia coli Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Mice, Transgenic

Share to Mutagens

Share to Mutation

Source

Identifiers

PMID: 8991063
DOI: 10.1002/(SICI)1098-2280(1996)28:4<348::AID-EM8>3.0.CO;2-7

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Organ variation in the mutagenicity of dimethylnitrosamine in Big Blue mice.PMID 8991063Read ↗

Frequency and spectrum of lacI mutations in the liver of Big Blue mice following the administration of genotoxic carcinogens singly and in series.Semantic proximity Read ↗

Target organ and time-course in the mutagenicity of five carcinogens in MutaMouse: a summary report of the second collaborative study of the transgenic mouse mutation assay by JEMS/MMS.Semantic proximity Read ↗

Specific mutational spectrum of dimethylnitrosamine in the lacI transgene of Big Blue C57BL/6 mice.Semantic proximity Read ↗

Gene- and tissue-specificity of mutation in Big Blue rats treated with the hepatocarcinogen N-hydroxy-2-acetylaminofluorene.Semantic proximity Read ↗

In vivo genotoxicity of 2-amino-3,8-dimethylimidazo[4, 5-f]quinoxaline in lacI transgenic (Big Blue) mice.Semantic proximity Read ↗

Evaluation of the in vivo genotoxic potential of three carcinogenic aromatic amines using the Big Blue transgenic mouse mutation assay.Semantic proximity Read ↗

Organ variation in the mutagenicity of ethylnitrosourea in Muta mouse: results of the collaborative study on the transgenic mutation assay by JEMS/MMS. The Collaborative Study Group for the Transgenic Mouse Mutation Assay Mammalian Mutagenesis Study Group of the Environmental Mutagen Society of Japan.Semantic proximity Read ↗

Organ-targeted mutagenicity of nitrofurantoin in Big Blue transgenic mice.Semantic proximity Read ↗

Genotoxicity of 3-methylcholanthrene in liver of transgenic big Blue mice.Semantic proximity Read ↗

Mutational spectrum of dimethylnitrosamine in the liver of 3- and 6-week-old lacI transgenic mice.Semantic proximity Read ↗

LacI transgenic animal study: relationships among DNA-adduct levels, mutant frequencies and cancer incidences.Semantic proximity Read ↗

Hepatic lacI and cII mutation in transgenic (lambdaLIZ) rats treated with dimethylnitrosamine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.