Article
Multistage gene expression profiling in a differentially susceptible mouse colon cancer model.
Cancer letters - 28 Feb 2003
Guda Kishore, Cui Hongyi, Garg Sanjeev, Dong Mei, Nambiar Prashant R, Achenie Luke E K, Rosenberg Daniel W
Abstract excerpt
The DNA alkylating agent, azoxymethane (AOM), induces tumor formation in the distal colon of susceptible mice. Differential susceptibility to this colonotropic carcinogen has been well characterized in A/J (sensitive) and AKR/J (resistant) mice. However, the reasons underlying the differential response to AOM and the molecular mechanisms involved in colon tumor progression remain unclear. To address these issues,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.