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Article

CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer

17 May 2006

Abstract excerpt

Genetic alterations occur during the adenoma-carcinoma sequence of colon cancer formation and drive the initiation and progression of colon cancer formation. The aberrant methylation of genes is an alternate, epigenetic mechanism for silencing tumor suppressor genes in colon cancer. The aim of this study was to determine on a global and gene-specific level the role of CpG island methylation in the initiation and...

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PMID: 16708352
DOI: 10.1002/gcc.20341

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