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Article

Mlh1 deficiency in normal mouse colon mucosa associates with chromosomally unstable colon cancer.

Carcinogenesis - 28 May 2018

Pussila Marjaana, Törönen Petri, Einarsdottir Elisabet, Katayama Shintaro, Krjutškov Kaarel, Holm Liisa, Kere Juha, Peltomäki Päivi, Mäkinen Markus J, Linden Jere, Nyström Minna

Abstract excerpt

Colorectal cancer (CRC) genome is unstable and different types of instabilities, such as chromosomal instability (CIN) and microsatellite instability (MSI) are thought to reflect distinct cancer initiating mechanisms. Although 85% of sporadic CRC reveal CIN, 15% reveal mismatch repair (MMR) malfunction and MSI, the hallmarks of Lynch syndrome with inherited heterozygous germline mutations in MMR genes. Our study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29701748
DOI: 10.1093/carcin/bgy056
PMCID: PMC5973430

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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