Article
Lack of gene deletion for complement C4A deficiency in Japanese patients with systemic lupus erythematosus.
The Journal of rheumatology - 1 Aug 1990
Yamada H, Watanabe A, Mimori A, Nakano K, Takeuchi F, Matsuta K, Tanimoto K, Miyamoto T, Yukiyama Y, Tokunaga K
Abstract excerpt
The frequency of C4A gene deletion was studied in Japanese patients with systemic lupus erythematosus (SLE) and was compared with healthy controls. DNA preparations were extracted from peripheral blood leukocytes from 59 patients with SLE and from 166 healthy persons, and digested by restriction enzymes. They were hybridized with C4 complementary DNA by the Southern blotting method and the deletion of C4A gene...
Topics
- Alleles
- Chromosome Deletion
- Complement C4a
- Heterozygote
- Humans
- Lupus Erythematosus, Systemic
- Phenotype
- Polymorphism, Restriction Fragment Length