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Article

Lack of evidence of a specific role for C4A gene deficiency in determining disease susceptibility among C4-deficient patients with systemic lupus erythematosus (SLE).

Clinical and experimental immunology - 1 Jan 2001

Dragon-Durey M A, Rougier N, Clauvel J P, Caillat-Zucman S, Remy P, Guillevin L, Liote F, Blouin J, Ariey F, Lambert B U, Kazatchkine M D, Weiss L

Abstract excerpt

The aim of the present study was to investigate the prevalence of C4 and C2 deficiencies and to characterize genomic alterations in C4 genes in a large cohort of 125 unselected patients with SLE. We determined the protein concentration and functional activity of C2 and C4, as well as the C4 phenotype. C4 genotyping included Taq 1 restricted fragment lengh polymorphism (RFLP) analysis and polymerase chain reaction...

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Identifiers

PMID: 11168010
DOI: 10.1046/j.1365-2249.2001.01438.x
PMCID: PMC1905972

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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