Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deficiency of C4A is a genetic determinant of systemic lupus erythematosus in three ethnic groups.

Journal of immunogenetics - 1 Jan 2000

Dunckley H, Gatenby P A, Hawkins B, Naito S, Serjeantson S W

Abstract excerpt

Systemic lupus erythematosus (SLE) has shown associations with the major histocompatibility complex (MHC) class II DR antigens and class III complement components C2 and C4 in previous studies. The primary susceptibility locus has been difficult to identify, however, on account of linkage disequilibrium within the MHC. We have studied C4A and C4B distributions in 63 Caucasoid, 75 Chinese and 51 Japanese SLE...

Topics

Alleles
Asian People
Australia
Chromosome Mapping
Complement C4
Complement C4a
Complement C4b
Gene Frequency
Genetic Linkage
HLA-DR Antigens
Hong Kong
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Japan

Lupus Erythematosus, Systemic

Phenotype

White People

Source

Identifiers

PMID: 3502648
DOI: 10.1111/j.1744-313x.1987.tb00383.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-3502648-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deficiency of C4A is a genetic determinant of systemic lupus erythematosus in three ethnic groups.PMID 3502648Read ↗

The intricate role of complement component C4 in human systemic lupus erythematosus.Semantic proximity Read ↗

Major histocompatibility complex (MHC) complement deficiency, ancestral haplotypes and systemic lupus erythematosus (SLE): C4 deficiency explains some but not all of the influence of the MHC.Semantic proximity Read ↗

Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.Semantic proximity Read ↗

Complement C4B null allele status confers risk for systemic lupus erythematosus in a Spanish population.Semantic proximity Read ↗

A study of the association of HLA DR, DQ, and complement C4 alleles with systemic lupus erythematosus in Iceland.Semantic proximity Read ↗

Human Complement C4B Allotypes and Deficiencies in Selected Cases With Autoimmune Diseases.Semantic proximity Read ↗

Effects of Complement <i>C4</i> Gene Copy Number Variations, Size Dichotomy, and <i>C4A</i> Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian PopulationsSemantic proximity Read ↗

C4A deficiency due to a 2 bp insertion is increased in patients with systemic lupus erythematosus.Semantic proximity Read ↗

Relative contributions of HLA-DQA and complement C4A loci in determining susceptibility to systemic lupus erythematosus.Semantic proximity Read ↗

HLA-B44031;DRB1*1503 and other sub-Saharan African major histocompatibility complex haplotypes in African Americans and Afro-Caribbeans carry C4A gene deletions: implications for ethnicity-specific lupus susceptibility genes.Semantic proximity Read ↗

The molecular basis of complete complement C4A and C4B deficiencies in a systemic lupus erythematosus patient with homozygous C4A and C4B mutant genes.Semantic proximity Read ↗

Molecular basis of complete complement C4 deficiency in two North-African families with systemic lupus erythematosusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.