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Article

DR3 and nonDR3 associated complement component C4A deficiency in systemic lupus erythematosus.

Clinical immunology and immunopathology - 1 Jul 1991

Kumar A, Kumar P, Schur P H

Abstract excerpt

The molecular basis of complement component C4A deficiency in white U.S. and Mexican patients with systemic lupus erythematosus (SLE) was studied. Genomic DNA from SLE patients and non-SLE controls was analyzed for restriction fragments using HindIII and a 5' C4 cDNA probe. C4A gene deletion was recognized by the loss of a 15-kb restriction fragment and the appearance of a 8.5-kb fragment. Thirty-two selected...

Topics

Alleles
Chromosome Deletion
Complement C4a
HLA-DR3 Antigen
Humans
Lupus Erythematosus, Systemic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2044237
DOI: 10.1016/0090-1229(91)90111-m

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2044237-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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DR3 and nonDR3 associated complement component C4A deficiency in systemic lupus erythematosus.PMID 2044237Read ↗

A rare complement component C4 restriction fragment length polymorphism in two families with systemic lupus erythematosus.Semantic proximity Read ↗

Restriction fragment length polymorphism analysis of HLA-DR, DQ, DP and C4 alleles in Caucasians with systemic lupus erythematosus.Semantic proximity Read ↗

Lack of gene deletion for complement C4A deficiency in Japanese patients with systemic lupus erythematosus.Semantic proximity Read ↗

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The phenotype of SLE associated with complete deficiency of complement isotype C4A.Semantic proximity Read ↗

Major histocompatibility complex class II and C4 alleles in Mexican Americans with systemic lupus erythematosus.Semantic proximity Read ↗

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Long PCR detection of the C4A null allele in B8-C4AQ0-C4B1-DR3.Semantic proximity Read ↗

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