Article
Lack of deletion of complement C4 and steroid 21-hydroxylase genes in Japanese patients with primary Sjögren's syndrome.
The Journal of rheumatology - 1 May 1992
Moriuchi J, Ichikawa Y, Takaya M, Shimizu H, Uchiyama M, Inoko H, Tsuji K, Arimori S
Abstract excerpt
A null allele at C4A (C4AQO) is associated with primary Sjögren's syndrome (SS) in Japanese. Since a deletion of the C4A and CyP21A genes is reported to account for C4AQO in patients with systemic lupus erythematosus (SLE) in Caucasians, we studied the restriction fragment length polymorphism (RFLP) of genomic DNA to determine whether similar deletions of the C4A and CyP21A genes occur in Japanese patients with...
Topics
- Alleles
- Blotting, Southern
- Chromosome Deletion
- Complement C4
- DNA
- DNA Probes
- Female
- Humans
- Japan
- Male
- Polymorphism, Restriction Fragment Length