Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.

doi:10.1136/ard.62.1.71

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Article

Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.

Annals of the rheumatic diseases - 1 Jan 2003

Man X-Y, Luo H-R, Li X-P, Yao Y-G, Mao C-Z, Zhang Y-P

Abstract excerpt

OBJECTIVE: To investigate the association of complement C4 null genes (C4Q0, including C4AQ0 and C4BQ0) and C2 gene with systemic lupus erythematosus (SLE) in southwest Han Chinese; 136 patients with SLE and 174 matched controls were genotyped. METHODS: C4 null genes were determined by a polymerase chain reaction (PCR) procedure with sequence specific primers (PCR-SSP). The 2 bp insertion in exon 29, which was...

Topics

Adolescent
Adult
Aged
Case-Control Studies
Child
China
Complement C2
Complement C4
Complement C4a
Complement C4b
Female
Gene Deletion
Gene Frequency
Genotype
Homozygote

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Identifiers

PMID: 12480675
DOI: 10.1136/ard.62.1.71
PMCID: PMC1754297

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Humans

Lupus Erythematosus, Systemic

Male