Confirmation of C4 gene copy number variation and the association with systemic lupus erythematosus in Chinese Han population.

doi:10.1007/s00296-011-2023-7

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Article

Confirmation of C4 gene copy number variation and the association with systemic lupus erythematosus in Chinese Han population.

Rheumatology international - 1 Oct 2012

Lv Yongmei, He Sumin, Zhang Zheng, Li Yang, Hu Dayan, Zhu Kunju, Cheng Hui, Zhou Fusheng, Chen Gang, Zheng Xiaodong, Li Pan, Ren Yunqing, Yin Xianyong, Cui Yong, Sun Liangdan, Yang Sen, Zhang Xuejun

Abstract excerpt

The distribution of complement component 4 (C4) gene copy number (GCN) has been validated in European populations. Meanwhile, C4 gene has been identified as a susceptibility gene for systemic lupus erythematosus (SLE). However, the association and the possible phenotype significance remain to be determined intensely in the Chinese population. This study was designed to validate the distribution of C4 GCNs in...

Topics

Adult
Asian People
Case-Control Studies
China
Complement C4
DNA Copy Number Variations
Female
Gene Dosage
Gene Frequency
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Lupus Erythematosus, Systemic

Male

Middle Aged

Odds Ratio

Phenotype

Real-Time Polymerase Chain Reaction

Risk Assessment

Source

Open in PubMed

Identifiers

PMID: 21904924
DOI: 10.1007/s00296-011-2023-7

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